Narcolepsy Risk DNA Test
Do you find yourself struggling to stay awake during the day, despite a full night’s sleep? The Genovate Narcolepsy Risk DNA Test may provide the answers you need. This test is designed to detect the presence of the HLA-DQB1*06:02 allele, which is strongly associated with narcolepsy, a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden attacks of sleep.
- Detects the HLA-DQB1*06:02 variant associated with narcolepsy
- Carriers of two copies of the allele have a 7X to 25X increased risk of developing narcolepsy.
- Receive 100% private and confidential online results
- Simple and painless mouth swab sample collection
What is Narcolepsy?
Narcolepsy is a sleep disorder that affects the brain’s ability to regulate sleep-wake cycles. Symptoms include excessive daytime sleepiness, sleep paralysis, hallucinations, and in some cases, cataplexy—sudden, brief loss of muscle tone. It is a condition that can significantly impact daily activities, making it difficult for sufferers to live a normal life.
How common is Narcolepsy?
Narcolepsy affects approximately 1 in 2000 to 1 in 5000 individuals, yet only about 25% receive an accurate diagnosis. Misdiagnoses are common, often attributing symptoms to psychiatric or emotional issues. Family members of affected individuals have a substantially increased risk, up to 20-40 times higher than the general population.
The Genovate Narcolepsy Risk DNA Test is a valuable tool for individuals experiencing symptoms of narcolepsy or those with a family history of the disorder.
The Genovate Narcolepsy Risk DNA Test identifies the presence of the HLA-DQB1*06:02 allele associated with narcolepsy, which is present in approximately 90-99% of individuals with narcolepsy. This allele is part of the human leukocyte antigen (HLA) system, which is crucial for the immune system’s ability to distinguish between self and non-self molecules.
- Having two copies of HLA-DQ1b*06:02 puts you at 7 to 25 times higher risk
- Having one copy of HLA-DQB1*06:02 along with another gene variant increases risk by 3 times
- If you don’t have HLA-DQB1*06:02, your risk of narcolepsy is lower
While the HLA-DQB1*06:02 allele is a significant genetic factor, it is important to note that not all individuals with this allele develop narcolepsy, indicating that other genetic and environmental factors also play a role in the condition.
Symptoms of Narcolepsy
- Excessive daytime sleepiness, making it difficult to concentrate and stay awake.
- Cataplexy, resulting in temporary loss of muscle control, often triggered by emotions such as laughter and anger.
- Sleep paralysis, causing a temporary inability to move or speak when waking up or falling asleep.
- Microsleeps, or brief episodes of sleep that can occur at any time.
- Memory problems, headaches, and restless sleep, including vivid nightmares and physically acting out dreams
- Hallucinations, particularly when going to sleep or waking up.
- Waking up frequently throughout the night or having trouble staying asleep.