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Narcolepsy Risk DNA Test


Do you find yourself struggling to stay awake during the day, despite a full night’s sleep? The Genovate Narcolepsy Risk DNA Test may provide the answers you need. This test is designed to detect the presence of the HLA-DQB1*06:02 allele, which is strongly associated with narcolepsy, a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden attacks of sleep.

  • Detects the HLA-DQB1*06:02 variant associated with narcolepsy
  • Carriers of two copies of the allele have a 7X to 25X increased risk of developing narcolepsy.
  • Receive 100% private and confidential online results
  • Simple and painless mouth swab sample collection
What is Narcolepsy?

Narcolepsy is a sleep disorder that affects the brain’s ability to regulate sleep-wake cycles. Symptoms include excessive daytime sleepiness, sleep paralysis, hallucinations, and in some cases, cataplexy—sudden, brief loss of muscle tone. It is a condition that can significantly impact daily activities, making it difficult for sufferers to live a normal life.

How common is Narcolepsy?

Narcolepsy affects approximately 1 in 2000 to 1 in 5000 individuals, yet only about 25% receive an accurate diagnosis. Misdiagnoses are common, often attributing symptoms to psychiatric or emotional issues. Family members of affected individuals have a substantially increased risk, up to 20-40 times higher than the general population.

The Genovate Narcolepsy Risk DNA Test is a valuable tool for individuals experiencing symptoms of narcolepsy or those with a family history of the disorder.

The Genovate Narcolepsy Risk DNA Test identifies the presence of the HLA-DQB1*06:02 allele associated with narcolepsy, which is present in approximately 90-99% of individuals with narcolepsy. This allele is part of the human leukocyte antigen (HLA) system, which is crucial for the immune system’s ability to distinguish between self and non-self molecules.

  • Having two copies of HLA-DQ1b*06:02 puts you at 7 to 25 times higher risk
  • Having one copy of HLA-DQB1*06:02 along with another gene variant increases risk by 3 times
  • If you don’t have HLA-DQB1*06:02, your risk of narcolepsy is lower

While the HLA-DQB1*06:02 allele is a significant genetic factor, it is important to note that not all individuals with this allele develop narcolepsy, indicating that other genetic and environmental factors also play a role in the condition.

Symptoms of Narcolepsy
  • Excessive daytime sleepiness, making it difficult to concentrate and stay awake.
  • Cataplexy, resulting in temporary loss of muscle control, often triggered by emotions such as laughter and anger.
  • Sleep paralysis, causing a temporary inability to move or speak when waking up or falling asleep.
  • Microsleeps, or brief episodes of sleep that can occur at any time.
  • Memory problems, headaches, and restless sleep, including vivid nightmares and physically acting out dreams
  • Hallucinations, particularly when going to sleep or waking up.
  • Waking up frequently throughout the night or having trouble staying asleep.

How it works

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