DNA Alcohol Intolerance Test
This test detects genetic variants that affect alcohol metabolism. Individuals that carry these variants increase their risk of unpleasant side effects and serious health complications if they consume alcohol.
- Immediate reactions: facial flushing, nausea, dizziness, headaches, increased heart rate, insomnia, severe hangovers
- Increased risk of esophageal cancer: 10X increased risk for moderate drinkers and up to a 90X increased risk for heavy drinkers
- Cardiovascular problems
- Memory loss
- Mental confusion
- Psychological issues
- ADH1B and ADH1C encode two members of the ADH family – the enzyme responsible for the conversion of ethanol to acetaldehyde (first step of alcohol metabolism). Genetic variants that increase ADH activity result in rapid build up of acetaldehyde.
- ALDH2 encodes a member of the ALDH family – the enzyme responsible for the conversion of acetaldehyde to acetate (second step of alcohol metabolism). A common variation in this gene decreases ALDH activity, slowing the removal of the toxic acetaldehyde.